More than 1 in every 5,000 individuals in the United States suffer from a mitochondrial disease. but it can be difficult to diagnosis or is often misdiagnosed. Dysfunctional mitochondria play a primary role in many different diseases ranging from very severe childhood diseases, Chronic Kidney Disease, and metabolic disorders to more common diseases, such as aging-related disorders. Inherited mitochondrial diseases, caused by genetic changes in the mtDNA, have no cure and very limited or no treatment options. More common age-related disorders may be addressed by correcting the dysfunctional mitochondrial. Primera is targeting all types of mitochondrial diseases with first-in-class gene editing therapeutics.